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Sleep and diabetic retinopathy
Author(s) -
Jee Donghyun,
Keum Nana,
Kang Seungbum,
Arroyo Jorge G.
Publication year - 2017
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.13169
Subject(s) - medicine , diabetes mellitus , diabetic retinopathy , body mass index , confidence interval , sleep (system call) , sleep deprivation , fundus (uterus) , national health and nutrition examination survey , retinopathy , pupil , confounding , population , ophthalmology , pediatrics , endocrinology , psychology , circadian rhythm , environmental health , neuroscience , computer science , operating system
Purpose To investigate the association between sleep duration and diabetic retinopathy ( DR ). Methods A population‐based cross‐sectional study using a nation‐wide, systemically stratified, multistage, clustered sampling method included a total of 1670 subjects aged ≥40 years with diabetes who participated in the Korean National Health and Nutrition Examination Survey during 2008–2012. All participants performed standardized interviews, including self‐reported sleep duration, and comprehensive ophthalmic examinations. Seven standard retinal fundus photographs were obtained from both eyes after pupil dilatation. Diabetic retinopathy (DR) was graded and classified as any DR and vision‐threatening DR . Participants were stratified into men and women. Results The mean sleep duration was 6.71 hr/day. In men, adjusted OR of any DR was 1.88 [95% confidence interval ( OR ), 1.01–3.59] in those with ≤5 hr sleep, and 2.19 (95% CI , 1.01–4.89) in those with ≥9 hr sleep, compared to in subjects with 6–8 hr sleep, after adjusting for potential confounders including age, body mass index (BMI), diabetes duration, fasting glucose level, haemoglobin A1c levels and hypertension. In women, however, no significant association between sleep duration and DR was found. The vision‐threatening DR was not significantly associated with sleep duration in either men or women. Conclusions Short and long sleep was associated with high prevalence of DR in men. Sleep deprivation may be involved in the pathogenesis of DR development.