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Retinal oxygen saturation in Chinese adolescents
Author(s) -
Liu Xue,
Wang Shuang,
Liu Yi,
Liu Li Juan,
Lv Yan Yun,
Tang Ping,
Jonas Jost B.,
Xu Liang
Publication year - 2017
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.13167
Subject(s) - quadrant (abdomen) , medicine , ophthalmology , retinal , oxygen saturation , linear regression , refractive error , saturation (graph theory) , oxygen , optometry , eye disease , surgery , mathematics , chemistry , statistics , organic chemistry , combinatorics
Purpose To study the retinal oxygen saturation in normal eyes of Chinese adolescents. Methods Performing retinal oximetry with the Oxymap T1 Retinal Oximeter in healthy children and adolescents (aged 5–18 years old), we measured the arterial (SaO 2 ) and venular (SvO 2 ) oxygen saturation and the arteriovenous difference in oxygen saturation (Sa‐ vO 2 ). Results The study included 122 individuals with a mean age of 13.0 ± 2.9 years (range: 5–18 years) and a mean refractive error of −3.25 ± 2.49 dioptres (range:−8.88 to +3.13 dioptres). Mean SaO 2 , SvO 2 and Sa‐ vO 2 was 85.5 ± 7.1%, 48.2 ± 5.5% and 37.3 ± 6.5%, respectively. Mean SaO 2 was significantly (p < 0.001) the lowest in the inferotemporal quadrant (79.1 ± 9.0%), followed by the superotemporal quadrant (83.4 ± 9.7%), the inferonasal quadrant (90.4 ± 10.6%) and the superonasal quadrant (93.4 ± 10.8%). In a similar manner, the values of the SvO 2 were the lowest (p < 0.001) in the inferotemporal quadrant (42.1 ± 8.3%), followed by the superotemporal quadrant (47.8 ± 7.2%), the inferonasal quadrant (52.3 ± 8.4%) and the superonasal quadrant (55.1 ± 7.6%). Arteriovenous difference in oxygen saturation (Sa‐vO 2 ) did not differ significantly (all p > 0.05) between the fundus quadrants. In multiple linear regression analysis, SaO 2 increased (regression coefficient r 2 = 0.28) with older age (standardized regression coefficient β : 0.23; p = 0.01) and more myopic refractive error ( β : −0.39; p < 0.001). Higher SvO 2 was significantly correlated with more myopic refractive error ( β : −0.46; p < 0.001; r 2 = 0.20), while Sa‐ vO 2 increased significantly only with older age in the multivariate analysis ( β : 0.26; p = 0.01; r 2 = 0.07). Conclusions Our study provides normative data for Chinese children and adolescents who showed lower values than adults for SaO 2 and SvO 2 . SaO 2 increased with older age and higher myopic refractive error, SvO 2 increased with higher myopic refractive error, and Sa‐ vO 2 increased with older age.