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Ocular morphology and visual function in relation to general growth in moderate‐to‐late preterm school‐aged children
Author(s) -
Raffa Lina H.,
Dahlgren Jovanna,
Hellström Ann,
Andersson Grönlund Marita
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.13085
Subject(s) - ophthalmology , medicine , visual acuity , retinal , birth weight , anthropometry , refractive error , optical coherence tomography , optometry , pregnancy , biology , genetics
Purpose To study ocular morphology and visual function in relation to general growth in moderate‐to‐late preterm ( MLP ) children. Methods Visual acuity ( VA ), refraction, optic disc parameters, biometric values and anthropometric measures were obtained from 50 eight‐year‐old MLP and 43 full‐term children. Macular parameters were examined by optical coherence tomography. Serum insulin‐like growth factor I ( IGF ‐I) levels were analysed at birth and at assessment and delta IGF ‐I was calculated. Results Total macular volume was significantly less in MLP than in controls (both eyes p < 0.01). Macular volume correlated with head circumference ( HCF ) at assessment [right eye (RE) p = 0.002, r = 0.67; left eyes ( LE ) p = 0.01, r = 0.54] and refraction (both eyes p < 0.05, r = 0.4) in the MLP children. Furthermore, central retinal thickness correlated significantly with delta IGF ‐I ( RE p = 0.03, r = −0.51, LE p = 0.006, r = −0.59) and refraction (both eyes p < 0.01, r = 0.5) and optic disc areas correlated with weight and height at assessment (all p < 0.05, r = 0.4). Total axial length correlated with HCF at assessment (both eyes p < 0.01, r = 0.5) and VA log MAR (both eyes p < 0.02, r = −0.4). Conclusions Macular volume was significantly less in MLP children than in controls examined at 8 years of age. General growth of children and IGF ‐I levels seem to be involved in development of ocular growth and morphology.