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Retinal vessel diameters in a Japanese population: the Locomotive Syndrome and Health Outcome in Aizu Cohort Study
Author(s) -
Tano Takatoshi,
Ono Koichi,
Hiratsuka Yoshimune,
Otani Koji,
Sekiguchi Miho,
Konno Shinichi,
Kikuchi Shinichi,
Onishi Yoshihiro,
Takegami Misa,
Yamada Masakazu,
Fukuhara Shunichi,
Murakami Akira
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.12953
Subject(s) - medicine , blood pressure , cohort , retinal , population , quartile , arteriole , prehypertension , ophthalmology , cardiology , physiology , microcirculation , confidence interval , environmental health
Purpose To describe the relationship between retinal vascular calibre and cardiovascular risk factors in a Japanese population. Methods The Locomotive Syndrome and Health Outcome in Aizu Cohort Study is a population‐based, cross‐sectional survey that included 2346 persons (56.1% of the eligible population) aged 40 to 74 years old. Retinal vascular calibre was measured from digital retinal photographs using a validated standardized protocol. Data on major cardiovascular risk factors were collected from all participants. Results Of the 1787 participants with available retinal vascular calibre data, the mean retinal arteriolar calibre ( CRAE ) was 141.6 ± 18.6 μ m, the mean venular calibre ( CRVE ) was 209.3 ± 26.1 μ m, and the mean arteriole‐to‐venule ratio was 0.68 ± 0.08. A smaller CRAE was associated with male sex, increasing quartiles of systolic blood pressure and diastolic blood pressure, history of hypertension, current alcohol intake and higher quartiles of serum creatinine. A larger CRAE was associated with increasing quartiles of total cholesterol. A larger CRVE was associated with current cigarette smoking. Multivariate analyses showed that a smaller CRAE was associated with male sex, elevated mean arterial blood pressure and a history of hypertension; and a larger CRVE was associated with cigarette smoking. Conclusions The results of this study suggest that a narrowed diameter of the retinal arteriole in Japanese people is related to hypertension and sex (male) and that an enlarged retina venular diameter is related to a history of smoking. The pattern of these associations is similar to that in white populations and other Asian populations.