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Heat shock protein‐70 and hypoxia inducible factor‐1 α in type 2 diabetes mellitus patients complicated with retinopathy
Author(s) -
Sayed Khulood M.,
Mahmoud Aida A.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.12919
Subject(s) - hsp70 , medicine , diabetic retinopathy , type 2 diabetes mellitus , diabetes mellitus , hypoxia (environmental) , hypoxia inducible factors , heat shock protein , shock (circulatory) , retinopathy , gastroenterology , endocrinology , biology , biochemistry , oxygen , chemistry , organic chemistry , gene
Purpose To elucidate the role of heat shock protein‐70 ( HSP 70) and hypoxia inducible factor‐1 α ( HIF ‐1 α ) in diabetic retinopathy ( DR ) patients. Design and methods A comparative study was done on the serum level of both HSP 70 and HIF ‐1 α in 50 patients with type 2 diabetes mellitus (T2 DM ) without DR , 50 patients with T2 DM and DR and 70 healthy control subjects. Results HSP 70 and HIF ‐1 α were significantly increased in T2 DM patients compared to controls and increased in patients with T2 DM & DR compared to T2 DM patients without DR (p < 0.0001). HSP 70 did not differ among the patients with different stages of DR , while HIF ‐1 α increased significantly in grades 3 and 4 DR patients compared to grades 1 and 2 DR patients. A strong correlation was found between HIF ‐1 α and the development of DR ( r = 0.835, p = 0.00) but not with HSP 70. HIF ‐1 α can be used as a predictor for development of DR but not HSP 70. Conclusions Our study was the first that investigated both HSP 70 and HIF ‐1 α in humans and was the first that measured their levels in serum of patients with DR . The study suggested that HSP 70 might have a protective function in T2 DM patients rather than a therapeutic function. HIF ‐1 α had an upper hand in the development and progression of DR . Induction of HSP 70 and blockage of HIF ‐1 α could lead to the development of novel prophylactic and therapeutic strategies for DR and potentially other diabetic complications.