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Symmetry in early response to intravitreal ranibizumab in bilateral diabetic macular oedema
Author(s) -
Guillard Margaux,
Dupas Bénédicte,
El Sanharawi Mohamed,
Erginay Ali,
Tadayoni Ramin,
Massin Pascale
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.12905
Subject(s) - ranibizumab , medicine , ophthalmology , visual acuity , retinal , diabetic macular edema , diabetic retinopathy , diabetes mellitus , surgery , endocrinology , bevacizumab , chemotherapy
Purpose To study the symmetry in response to bilateral diabetic macular oedema ( DME ) treated with bilateral intravitreal injections of ranibizumab ( IVR ). Methods The charts of 36 eyes of 18 patients treated with a loading dose of three monthly IVR in both eyes were retrospectively reviewed. Favourable anatomical response was defined as a decrease by more than 10% in baseline central macular thickness ( CMT ), and favourable functional response was defined as an increase in visual acuity ( VA ) ≥5 letters. A symmetric response was defined as a similar anatomical and/or functional response in the first ( FE ) and second ( SE ) treated eyes. Results The VA improved significantly after ranibizumab treatment in both eyes (p < 0.01). A statistically significant positive correlation was found for the functional response to ranibizumab between the FE and the SE ( R 2 = 0.26, p = 0.03). The mean CMT decreased significantly in both eyes (p < 0.01). A strong positive correlation was observed between the anatomical response to ranibizumab in the FE and the SE ( R 2 = 0.37, p = 0.01). Symmetric favourable anatomical and functional responses were observed in 13 patients (72%). In two additional patients, an asymmetric functional response was observed despite a decrease in retinal thickness in both eyes. Conclusion Symmetric anatomical and functional responses were observed in 72% of patients with DME after three initial IVR in each eye. This finding could be of clinical interest in the decision to treat the fellow eye, in a disease where a bilateral involvement is frequent.