Bilateral uveal melanomas with different gene expression detected with 7 years interval | Zendy

Eide Nils | Zendy; Garred Øystein | Zendy; Beiske Klaus | Zendy; Fodstad Øystein | Zendy

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Bilateral uveal melanomas with different gene expression detected with 7 years interval

Author(s) -

Eide Nils,

Garred Øystein,

Beiske Klaus,

Fodstad Øystein

Publication year - 2016

Publication title -

acta ophthalmologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.534

H-Index - 87

eISSN - 1755-3768

pISSN - 1755-375X

DOI - 10.1111/aos.12857

Subject(s) - enucleation , melanoma , medicine , bap1 , monosomy , pathology , uvea , micrometastasis , ciliary body , dermatology , ophthalmology , metastasis , gene , biology , cancer research , cancer , surgery , genetics , karyotype , chromosome

Purpose To report a bilateral uveal melanoma detected in a micrometastasis study. Method Case report. Results At enucleation of a circumpapillary amelanotic mixed melanoma in a patient with ocular melanocytosis, a pigmented lesion in the other eye was detected, thought to be a naevus. BAP 1 was positive showing nuclear staining of the tumour cells. Seven years later the naevus showed growth and development of a retinal detachment. FNAB disclosed monosomy 3 in the spindle tumour cells. Conclusion A case of bilateral melanoma with long‐term survival without metastatic diseases is reported. Different gene expressions in the two eyes were revealed. The case is a reminder that follow‐up over years is essential in patients with a uveal melanoma, especially with ocular melanocytosis.

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