Premium
Progression of visual field in patients with primary open‐angle glaucoma – P rog F study 1
Author(s) -
Aptel Florent,
AryalCharles Nishal,
Giraud JeanMarie,
El Chehab Hussam,
Delbarre Maxime,
Chiquet Christophe,
Romanet JeanPaul,
Renard JeanPaul
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.12788
Subject(s) - glaucoma , medicine , ophthalmology , visual field , open angle glaucoma , absolute deviation , intraocular pressure , ocular hypertension , statistics , mathematics
Abstract Purpose To evaluate the visual field rate of progression of patients with treated ocular hypertension ( OHT ) and primary open‐angle glaucoma ( POAG ) in clinical practice, using the mean deviation ( MD ) and the visual field index ( VFI ). Methods Non‐interventional cohort study. From a large multicentre database representative of the French population, 441 eyes of 228 patients with treated OHT or POAG followed up at least 6 years with Humphrey 24.2 Sita‐Standard visual field examination at least twice a year were identified. From initial data, eyes were classified in five groups: 121 with OHT , 188 with early glaucoma ( MD greater than −6 dB), 45 with moderate glaucoma ( MD −6 to −12 dB), 41 with advanced glaucoma ( MD −12 to −18 dB) and 46 with severe glaucoma ( MD less than −18 dB). Rate of progression during the follow‐up period was calculated using the trend analysis of the Guided Progression Analysis software. Results The mean duration of follow‐up was 8.4 ± 2.7 years and the mean number of visual field, 18.4 ± 3.5. In eyes with OHT , rate of progression was −0.09 dB/year (−0.17% VFI /year). In eyes with POAG , rate of progression was −0.32 dB/year (−0.83% VFI /year) in eyes with early glaucoma, −0.52 dB/year (−1.81% VFI /year) in moderate glaucoma, −0.54 dB/year (−2.35% VFI /year) in advanced glaucoma and −0.45 dB/year (−1.97% VFI /year) in severe glaucoma. In eyes with POAG , a significant progression (p < 0.05) was detected in 159 of 320 eyes (49.7%) with trend analysis and 117 of 320 eyes (36.6%, likely progression) or 183 of 320 eyes (57.2%, possible and likely progression) with event analysis. Conclusions Primary open‐angle glaucoma is a progressive disease in the majority of patients despite cautioned treatment and follow‐up. The rate of progression varies greatly among subjects.