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Comparison of ketorolac 0.45% versus diclofenac 0.1% for macular thickness and volume after uncomplicated cataract surgery
Author(s) -
Lee Tae Hee,
Choi Won,
Ji Yong Sok,
Yoon Kyung Chul
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.12780
Subject(s) - ketorolac , medicine , diclofenac , ophthalmology , cataract surgery , optical coherence tomography , surgery , anesthesia , analgesic
Purpose To compare the effects of ketorolac 0.45% and diclofenac 0.1% on macular thickness and volume after uncomplicated cataract surgery. Methods A total of 76 eyes of 76 patients who underwent uncomplicated cataract surgery were included. Patients were treated with either diclofenac 0.1% (38 eyes) or ketorolac 0.45% (38 eyes) after surgery. The macular thickness and volume were obtained with optical coherence tomography ( OCT ). Central subfield thickness ( CST , OCT 1 mm zone), total foveal thickness ( TFT , OCT 3 mm zone), total macular thickness ( TMT , OCT 6 mm zone), average macular thickness (AMT) and total macular volume ( TMV ) were compared between the two study groups. Results No significant differences between groups were found in macular thickness or volume 1 month after cataract surgery. Two months after surgery, the ketorolac group had significantly lower CST , TFT , TMT and AMT than the diclofenac group (p < 0.05 for all). Additionally, 1 and 2 months after surgery, changes from preoperative values in CST (both p = 0.04), AMT (p = 0.02 and p < 0.01, respectively) and TMV (both p = 0.04) were significantly less in the ketorolac group than in the diclofenac group. Conclusions Following uncomplicated cataract surgery, topical ketorolac 0.45% was more effective than diclofenac 0.1% in preventing increases in macular thickness and volume.