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Morning Glory Disc Anomaly in childhood – a population‐based study
Author(s) -
Ceynowa Dylan J,
Wickström Ronny,
Olsson Monica,
Ek Ulla,
Eriksson Urban,
Wiberg Maria Kristoffersen,
Fahnehjelm Kristina Teär
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.12778
Subject(s) - medicine , ophthalmology , visual acuity , strabismus , population , environmental health
Purpose To report prevalence, ocular characteristics and coexisting neurological, behavioural, somatic and neuroradiological abnormalities in children and adolescents with morning glory disc anomaly ( MGDA ). Methods In a cross‐sectional population‐based study, 12 patients with MGDA , aged 2–20 years, were identified. All 12 agreed to ophthalmological assessments including visual functions, refraction, fundus photography, optical coherence tomography ( OCT ) and ocular motor score ( OMS ). Neurological examinations and behavioural/developmental screening were carried out. Data from previous or new neuroradiological investigations were collected. Results The prevalence of MGDA was 2.6/100 000. MGDA was unilateral in 11/12 patients with a best‐corrected visual acuity ( BCVA ) in the MGDA eye ranging from hand motion to 0.65 (median 0.06). Severe microphthalmus prevented unilaterality to be determined in one adolescent. All patients had a binocular BCVA of ≥0.5. OMS showed abnormalities in pupil response, vestibulo‐ocular reflex, stereo visual acuity, strabismus and convergence. OCT revealed peripapillary or macular oedema in 5/8 patients and foveal aplasia in 3/8 patients. Three patients had extensive capillary hemangiomas, of which one had PHACES syndrome and one had additional cerebrovascular anomalies and corpus callosum agenesis. Neuroradiology showed craniovascular anomalies in two patients. Neurology was mostly normal. Behavioural/developmental screening showed attention deficit hyperactivity disorder in one patient. Conclusions The prevalence data, previously not reported, of morning glory disc anomaly was 2.6/100 000. Coexisting retinal peripapillary or macular oedema was common, as were cerebral abnormalities and/or cutaneous vascular malformations. The associated findings may not be discovered through routine ophthalmological examination why OCT and neuroimaging are called for.