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Choroidal abnormalities in neurofibromatosis type 1 detected by near‐infrared reflectance imaging in paediatric population
Author(s) -
Vagge Aldo,
Camicione Paola,
Capris Cristina,
Sburlati Carlo,
Panarello Simona,
Calevo Maria Grazia,
Traverso Carlo Enrico,
Capris Paolo
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.12750
Subject(s) - medicine , neurofibromatosis , fundus (uterus) , ophthalmoscopy , ophthalmology , posterior pole , retinal , radiology
Purpose To investigate choroidal abnormalities in paediatric patients with neurofibromatosis type 1 ( NF 1) detected by near‐infrared reflectance ( NIR ) retinography in order to evaluate diagnostic accuracy. Methods Seventy‐eight paediatric patients with NF 1, diagnosed according to the National Institutes of Health ( NIH ) criteria, and 96 healthy control subjects matched for age were examined. Enrolled patients were under 16 years old. The presence of choroidal abnormalities was investigated by confocal scanning laser ophthalmoscopy. Main outcome measure was to evaluate diagnostic accuracy in paediatric patients compared with the NIH criteria. Results Seventy‐eight patients with NF 1 (41 female, 37 male; mean age 8.1 ± 3.5 years) were compared with 96 healthy control subjects (42 female, 54 male; mean age 8 ± 3 years). Choroidal abnormalities were observed in 54 (69.2%) of the patients with NF 1. As regards the fundus topographical distribution, choroidal abnormalities were more frequent at the posterior pole with a statistically significant correlation between patient age and the number of involved choroidal areas (Spearman r = 0.23; p < 0.04). No choroidal abnormalities were present in the control group. Detection accuracy of choroidal nodules was 70%. Conclusion Choroidal abnormalities appearing as bright patchy regions detected by NIR imaging occurred very frequently in paediatric patients affected by NF 1. The present study appears to show that NIR used to detect choroidal involvement allows for elevated diagnostic accuracy.