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Change in corneal hysteresis over time in normal, glaucomatous and diabetic eyes
Author(s) -
Hussnain Syed Amal,
Alsberge Joseph B.,
Ehrlich Joshua R.,
Shimmyo Mitsugu,
Radcliffe Nathan M.
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.12726
Subject(s) - medicine , ophthalmology , glaucoma , open angle glaucoma , ocular hypertension , logistic regression
Purpose Corneal hysteresis ( CH ) is lower in glaucomatous eyes. The aim of this study was to determine and compare the change in CH over time between normal, open angle glaucoma ( POAG ) and diabetic subjects. Methods We retrospectively analysed records of patients undergoing assessment with the Ocular Response Analyzer (Reichert, Corp., New York, NY, USA ). Right eyes with at least 7 measurements were included. Patients with ocular pathology other than POAG were excluded. Two‐sample t‐tests, chi‐squared and logistic regression were used to analyse data. Results A total of 1418 normal and 322 POAG patients were included. Patients with POAG were significantly older (70.73 ± 11.33 vs. 61.59 ± 16.56 years; p < 0.001), had a longer follow‐up (4.14 ± 1.34 vs. 2.72 ± 1.49 years; p < 0.001) and had lower CH (9.58 ± 2.17 vs. 9.95 ± 2.19 mmHg p = 0.01), but there were no gender differences between groups (61.5 vs. 57.7% female; p = 0.21). We observed a significantly greater decrease in CH among patients with POAG (−0.11 ± 0.73 vs. 0.07 ± 2.31 mm Hg/year; p = 0.02). The relation between ∆ CH /year and diagnosis persisted after adjusting for age and follow‐up time ( OR 0.90; 95% CI 0.82, 0.99; p = 0.03). We found CH to be higher in diabetics vs. non‐diabetics (10.34 ± 2.04 vs. 9.88 ± 2.19; p = 0.02), but ∆ CH /year was not different (0.07 ± 1.27 vs. 0.03 ± 2.10; p = 0.77). Conclusions Patients with POAG in this study had a significantly greater rate of CH decline compared to normal. There was no significant difference in rate of CH change in diabetic and non‐diabetic patients.