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Atypical birefringence pattern and the diagnostic ability of scanning laser polarimetry with enhanced corneal compensation in glaucoma
Author(s) -
Rao Harsha L.,
Yadav Ravi K.,
Begum Viquar U.,
Addepalli Uday K.,
Senthil Sirisha,
Choudhari Nikhil S.,
Garudadri Chandra S.
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.12524
Subject(s) - scanning laser polarimetry , ophthalmology , glaucoma , receiver operating characteristic , medicine , nerve fiber layer , balayage , laser , optics , physics
Purpose To evaluate the effect of typical scan score ( TSS ), when within the acceptable limits, on the diagnostic performance of retinal nerve fibre layer ( RNFL ) parameters with the enhanced corneal compensation ( ECC ) protocol of scanning laser polarimetry ( SLP ) in glaucoma. Methods In a cross‐sectional study, 203 eyes of 160 glaucoma patients and 140 eyes of 104 control subjects underwent RNFL imaging with the ECC protocol of SLP . TSS was used to quantify atypical birefringence pattern ( ABP ) images. Influence of TSS on the diagnostic ability of SLP parameters was evaluated by receiver operating characteristic ( ROC ) regression models after adjusting for the effect of disease severity [based on mean deviation ( MD )] on standard automated perimetry). Results Diagnostic abilities of all RNFL parameters of SLP increased when the TSS values were higher. This effect was statistically significant for TSNIT (coefficient: 0.08, p < 0.001) and inferior average parameters (coefficient: 0.06, p = 0.002) but not for nerve fibre indicator ( NFI , coefficient: 0.03, p = 0.21). In early glaucoma ( MD of −5 dB ), predicted area under ROC curve ( AUC ) for TSNIT average parameter improved from 0.642 at a TSS of 90 to 0.845 at a TSS of 100. In advanced glaucoma ( MD of −15 dB ), AUC for TSNIT average improved from 0.832 at a TSS of 90 to 0.947 at 100. Conclusion Diagnostic performances of TSNIT and inferior average RNFL parameters with ECC protocol of SLP were significantly influenced by TSS even when the TSS values were within the acceptable limits. Diagnostic ability of NFI was unaffected by TSS values.