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1090 nm infrared radiation at close to threshold dose induces cataract with a time delay
Author(s) -
Yu Zhaohua,
Schulmeister Karl,
Talebizadeh Nooshin,
Kronschläger Martin,
Söderberg Per G.
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.12508
Subject(s) - radiation , scattering , medicine , lens (geology) , radiation exposure , optics , ophthalmology , nuclear medicine , physics
Purpose To investigate whether infrared radiation (IRR)‐induced cataract is instant or is associated with a time delay between the exposure and the onset of lens light scattering after an exposure to just above threshold dose. Methods Six‐weeks‐old albino Sprague‐Dawley female rats were unilaterally exposed to 197 W/cm 2 IRR at 1090 nm within the dilated pupil. In the first experiment, the animals were exposed with four exposure times of 5, 8, 13 and 20 second, respectively. At 24 hr after exposure, the light scattering in both exposed and contralateral not exposed lenses was measured. Based on the first experiment, four postexposure time groups were exposed unilaterally to 1090 nm IRR of 197 W/cm 2 for 8 second. At 6, 18, 55 and 168 hr after exposure, the light scattering in both lenses was measured. Results A 197 W/cm 2 IRR‐induced light scattering in the lens with exposures of at least 8 second. Further, after exposure to IRR of 197 W/cm 2 for 8 second, the light‐scattering increase in the lens was delayed approximately 16 hr after the exposure. Conclusion There is a time delay between the exposure and the onset of cataract after exposure to close to threshold dose implicating that either near IRR cataract is photochemical or there is a time delay in the biological expression of thermally induced damage.