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Comparison of macular GCIPL and peripapillary RNFL deviation maps for detection of glaucomatous eye with localized RNFL defect
Author(s) -
Kim Mi Jeung,
Park Ki Ho,
Yoo Beong Wook,
Jeoung Jin Wook,
Kim Hee Chan,
Kim Dong Myung
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.12485
Subject(s) - ophthalmology , medicine , glaucoma , absolute deviation , retinal , nerve fiber layer , receiver operating characteristic , optometry , mathematics , statistics
Purpose To evaluate the ability of the deviation map of macular ganglion cell–inner plexiform layer ( GCIPL ) thickness compared with that of peripapillary retinal nerve fibre layer (p RNFL ) thickness for detection of localized RNFL defects shown on red‐free RNFL photography. Methods This prospective cross‐sectional study included 69 eyes of 69 subjects with preperimetric or perimetric glaucoma (mean deviation ( MD ) >−12d B ) and localized RNFL defects along with 79 eyes of 79 normal control subjects. The number of abnormal superpixels on the both macular GCIPL and p RNFL deviation maps by C irrus OCT corresponding to localized RNFL defects was calculated using a customized M atlab program and presented as severity indices according to each of the probability levels. The areas under the receiver operating characteristic curves ( AUROC s) of the severity indices were compared between the two deviation maps. Results According to three criteria and corresponding probability levels, the AUROC s of the GCIPL and p RNFL deviation maps ranged from 0.910 to 0.931 and 0.934 to 0.950, respectively. However, the differences were not statistically significant (all p > 0.05). Significant correlations were observed between the severity indices of the GCIPL deviation map and those of the p RNFL deviation map, regardless of the criteria (all p < 0.0001). Conclusions In the detection of glaucomatous eyes with localized RNFL defects, the macular GCIPL thickness deviation map showed a level of diagnostic performance comparable to that of the p RNFL thickness deviation map.