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Grader learning effect and reproducibility of Doppler Spectral‐Domain Optical Coherence Tomography derived retinal blood flow measurements
Author(s) -
Rose Kalpana,
Jong Monica,
Yusof Firdaus,
Tayyari Faryan,
Tan Ou,
Huang David,
Sadda Srinivas R,
Flanagan John G,
Hudson Christopher
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.12479
Subject(s) - repeatability , reproducibility , optical coherence tomography , medicine , retinal , ophthalmology , session (web analytics) , grading (engineering) , nuclear medicine , biomedical engineering , computer science , mathematics , statistics , world wide web , civil engineering , engineering
Purpose To investigate grader learning effect and to quantify intergrader reproducibility of Doppler Spectral‐Domain Optical Coherence Tomography ( SD ‐ OCT ) derived retinal blood flow measurements. Methods Fifteen healthy young subjects (mean age 28.44; SD 3 years) underwent Doppler SD ‐ OCT scans of one eye using the circumpapillary double circular scan protocol of the Optovue RTV ue by one of two experienced operators. One trained (i.e. having undergone certification) and one novice (i.e. preliminary training comprising five standard practice data sets) individual then graded a standardized set of scans, consisting of 15 data sets (session 1) using custom Doppler Optical Coherence Tomography of Retinal Circulation ( doctorc ) software. One week later (session 2), the novice grader underwent further training by grading an additional 15 practice data sets and then both graders subsequently regraded the original 15 data sets. Results Measurements achieved by a novice grader during session 1 showed a trend to be higher in terms of total retinal venous blood flow ( TRBF ) and also to be significantly (p = 0.03) higher for venous area, compared with a trained grader. Session 2 results were not significantly different for either grader. The mean TRBF for session 2 for the trained and novice grader was 45.29 ± 9.28 μl/min and 44.39 ± 7.36 μl/min, respectively. The coefficient of repeatability ( COR ) of session 2 TRBF values between the trained and novice grader was 8.09 μl/min. Conclusions There is a grader learning effect which impacts the venous area measurements. Reproducible and repeatable retinal blood flow measurements were achieved among trained graders using doctorc software.