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Effect of diquafosol ophthalmic solution on the optical quality of the eyes in patients with aqueous‐deficient dry eye
Author(s) -
Koh Shizuka,
Maeda Naoyuki,
Ikeda Chikako,
Oie Yoshinori,
Soma Takeshi,
Tsujikawa Motokazu,
Watanabe Hitoshi,
Nishida Kohji
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.12443
Subject(s) - ophthalmology , medicine , eye drop
Abstract Purpose To investigate the short‐ and long‐term effects of diquafosol ophthalmic solution on the optical quality of the eyes in patients with aqueous‐deficient dry eye. Methods Sixteen eyes in 16 patients with mild or moderate aqueous‐deficient dry eye were treated with 3% diquafosol ophthalmic solution. Ocular higher‐order aberrations ( HOA s) were measured with a wavefront sensor before and at 15 min after diquafosol instillation at the baseline visit and at 4 weeks after treatment initiation. Dry eye symptoms, tear break‐up time ( BUT ), corneal/conjunctival fluorescein staining and S chirmer's test were also evaluated before and after treatment with diquafosol. Results Treatment with diquafosol ophthalmic solution significantly improved dry eye symptoms, corneal staining and BUT . Compared with mean total HOA s at baseline (0.180 ± 0.06 μm), those at 4 weeks after treatment significantly decreased (0.148 ± 0.039 μm; p = 0.035), whereas those 15 min after diquafosol instillation at the baseline visit did not change significantly (0.170 ± 0.049 μm; p = 0.279). Conclusions Although no significant change in HOA s was observed as a short‐term effect of a single‐drop instillation of diquafosol, long‐term use of diquafosol to treat aqueous‐deficient dry eye reduced HOA s as well as improved corneal epithelial damage and tear film stability.