Plasma vitamin D and serum total immunoglobulin E levels in patients with seasonal allergic conjunctivitis

Purpose To evaluate plasma 25‐hydroxyvitamin D and serum total immunoglobulin E ( IgE ) levels in patients with seasonal allergic conjunctivitis ( SAC ). Methods This observational case–control study involved 49 patients with SAC without any other ocular and systemic diseases, and 44 consecutive, age‐ and sex‐matched healthy subjects. Plasma 25‐hydroxyvitamin D and serum total IgE levels of all subjects were quantified with electrochemiluminescence technique. Results were compared between the groups, and p values of <0.05 were considered as statistically significant. Results No significant differences were found between the groups with respect to age (p = 0.41) and sex (p = 0.98). Plasma vitamin D levels of the subjects with SAC (median 8.03 ng/ml, range 3.00–17.97 ng/ml) were significantly lower than the control group (median 10.52 ng/ml, range 3.30–25.92 ng/ml) (p = 0.007). Serum total IgE levels of patients with SAC (median 48.65 IU/ml, range 1.77–812.00 IU/ml) were significantly higher when compared to the control group (median 32.49 IU/ml, range 0.14–104.60 IU/ml) (p = 0.003). Conclusions We found lower plasma vitamin D levels and higher serum total IgE levels in patients with SAC .