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Relationship between supernormal sectors of retinal nerve fibre layer and axial length in normal eyes
Author(s) -
Yamashita Takehiro,
Kii Yuya,
Tanaka Minoru,
Yoshinaga Wakako,
Yamashita Toshifumi,
Nakao Kumiko,
Sakamoto Taiji
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.12382
Subject(s) - nerve fibre layer , retinal , ophthalmology , medicine , nerve fiber layer , anatomy , optometry
Purpose To determine the effect of the axial length on the supernormal and false‐positive sectors of the peripapillary retinal nerve fibre layer ( RNFL ) in healthy eyes using the normative database embedded in a spectral domain optical coherence tomographic ( SD ‐ OCT ) instrument. Methods This was a prospective, observational cross ‐sectional study. The right eyes of 126 healthy young volunteers were studied. The RNFL thickness was measured by SD ‐ OCT in twelve 30‐degree sectors (clock hours) around the optic disc. The sectors whose RNFL thickness was <5% probability level were labelled as false‐positive sectors. The sectors >95% probability level were labelled as supernormal sectors. The relationships between the axial length and rates of supernormal and false‐positive sectors were investigated. Results A longer axial length was significantly associated with an increase in the rates of supernormal thickness in sector 8 (odds ratio, [ OR ], 1.494; p = 0.010) and sector 10 ( OR , 1.529; p = 0.008). The supernormal sectors were mainly located in the temporal region. A longer axial length was significantly associated with a higher rates of false positives in sector 5 ( OR , 1.789; p = 0.017), sector 6 ( OR , 2.305; p < 0.001) and sector 12 ( OR , 2.277 ; p = 0.035). Conclusions The axial length was significantly related to the rates of supernormal and false‐positive sectors even in healthy eyes. These findings indicate that the specificity and sensitivity of SD ‐ OCT will be affected especially in eyes with longer axial lengths.