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Ocular pulse amplitude and Doppler waveform analysis in glaucoma patients
Author(s) -
Abegão Pinto Luís,
Vandewalle Evelien,
Willekens Koen,
MarquesNeves Carlos,
Stalmans Ingeborg
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.12340
Subject(s) - medicine , glaucoma , normal tension glaucoma , ophthalmic artery , ophthalmology , central retinal artery , blood pressure , cardiology , diastole , pulse pressure , open angle glaucoma , intraocular pressure , blood flow
Purpose To determine the correlation between ocular blood flow velocities and ocular pulse amplitude ( OPA ) in glaucoma patients using colour Doppler imaging ( CDI ) waveform analysis. Method A prospective, observer‐masked, case‐control study was performed. OPA and blood flow variables from central retinal artery and vein ( CRA , CRV ), nasal and temporal short posterior ciliary arteries ( NPCA , TPCA ) and ophthalmic artery ( OA ) were obtained through dynamic contour tonometry and CDI , respectively. Univariate and multiple regression analyses were performed to explore the correlations between OPA and retrobulbar CDI waveform and systemic cardiovascular parameters (blood pressure, blood pressure amplitude, mean ocular perfusion pressure and peripheral pulse). Results One hundred and ninety‐two patients were included [healthy controls: 55; primary open‐angle glaucoma ( POAG ): 74; normal‐tension glaucoma ( NTG ): 63]. OPA was statistically different between groups (Healthy: 3.17 ± 1.2 mmHg; NTG : 2.58 ± 1.2 mmHg; POAG : 2.60 ± 1.1 mmHg; p < 0.01), but not between the glaucoma groups (p = 0.60). Multiple regression models to explain OPA variance were made for each cohort (healthy: p < 0.001, r = 0.605; NTG : p = 0.003, r = 0.372; POAG : p < 0.001, r = 0.412). OPA was independently associated with retrobulbar CDI parameters in the healthy subjects and POAG patients (healthy CRV resistance index: β = 3.37, CI : 0.16–6.59; healthy NPCA mean systolic/diastolic velocity ratio: β = 1.34, CI : 0.52–2.15; POAG TPCA mean systolic velocity: β = 0.14, CI 0.05–0.23). OPA in the NTG group was associated with diastolic blood pressure and pulse rate ( β = −0.04, CI : −0.06 to −0.01; β = −0.04, CI : −0.06 to −0.001, respectively). Conclusions Vascular‐related models provide a better explanation to OPA variance in healthy individuals than in glaucoma patients. The variables that influence OPA seem to be different in healthy, POAG and NTG patients.