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Vitamin D and intraocular pressure – results from a case –control and an intervention study
Author(s) -
Krefting Einar Andreas,
Jorde Rolf,
Christoffersen Terje,
Grimnes Guri
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.12125
Subject(s) - medicine , intraocular pressure , placebo , vitamin d and neurology , population , randomized controlled trial , vitamin , ophthalmology , gastroenterology , pathology , alternative medicine , environmental health
. Purpose: To study the associations between serum 25‐hydroxy‐vitamin D (25(OH)D) levels, vitamin D administration and intraocular pressure (IOP). Methods: The design of the study included a nested case–control study and a randomized controlled intervention trial. In the first part, healthy Caucasians with high or low serum 25(OH)D levels were recruited from a population‐based study. IOP of the right eye was measured by the use of a rebound tonometer. In the second part, those with low serum 25(OH)D levels were randomized to receive either capsules of vitamin D 3 20 000 IU twice per week or placebo for 6 months before IOP was measured again. Results: Intraocular pressure in the 87 participants with low serum 25(OH)D levels (mean 40.1 ± 12.9 n m ) did not differ from IOP in the 42 participants with high serum 25(OH)D levels (mean 85.1 ± 14.0 n m ) (15.9 ± 3.3 mmHg versus 15.6 ± 3.1 mmHg, p = 0.56, independent t ‐test). After intervention, IOP decreased by −0.8 ± 2.1 mmHg (p = 0.017, paired t ‐test) in the vitamin D group ( n = 39) and −0.8 ± 2.5 mmHg (p = 0.059) in the placebo group ( n = 39), but the change was not significantly different between the groups (p = 0.92, independent t ‐test). Conclusion: This study in healthy participants revealed no associations between serum 25(OH)D levels and IOP, and administration of vitamin D 3 to participants with low levels of 25(OH)D did not affect IOP. These results do not support a role of vitamin D in the regulation of IOP.