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Retinal vascular caliber is associated with renal function in apparently healthy subjects
Author(s) -
Daien Vincent,
Kawasaki Ryo,
Villain Max,
Ribstein Jean,
Du Cailar Guilhem,
Mimran Albert,
Fesler Pierre
Publication year - 2013
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.12094
Subject(s) - renal function , creatinine , medicine , retinal , urinary system , retinal artery , central retinal artery , kidney , urology , confounding , endocrinology , diabetes mellitus , cardiology , ophthalmology
. Purpose:  To assess the relation between retinal vascular caliber and renal function. Patients and methods:  Eighty apparently healthy subjects screened for cardiovascular risk factors (mean age 47 years, 51% female, 36% hypertensive, without diabetes or renal dysfunction) were recruited. Retinal vascular calibers were measured from fundus photographs and expressed as central retinal artery and venular equivalent. Renal function was assessed by measurement of glomerular filtration rate (urinary clearance of 99mTc‐DTPA) and urinary albumin/creatinine ratio. Results:  Mean glomerular filtration rate was 117 ml/min/1.73m 2 . Overall, central retinal artery and venular equivalent were positively correlated with glomerular filtration rate ( r  = +0.31, p   = 0.005 and r  = +0.30, p = 0.006, respectively). In addition, central retinal artery equivalent was negatively correlated with urinary albumin/creatinine ratio ( r  = −0.34, p = 0.002). No significant relationship was found between central retinal venular equivalent and urinary albumin/creatinine ratio ( r  = +0.12, p = 0.32). The observed relations between retinal vascular calibers and renal function parameters remained significant after adjusting for potential confounding factors. Conclusion:  In apparently healthy subjects with normal renal function, retinal arteriolar and venular calibers were negatively correlated with kidney function, suggesting common determinants of these preclinical target organ damages.

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