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An improved method to estimate absolute blood volume based on dialysate dilution
Author(s) -
Kron Susanne,
Schneditz Daniel,
Keane David F.,
Leimbach Til,
Kron Joachim
Publication year - 2021
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/aor.13970
Subject(s) - reproducibility , ultrafiltration (renal) , blood volume , volume (thermodynamics) , extracorporeal circulation , dilution , dialysis , biomedical engineering , chromatography , medicine , chemistry , surgery , anesthesia , quantum mechanics , thermodynamics , physics
Online hemodiafiltration machines equipped with a blood volume monitor and the possibility to rapidly infuse exact amounts of ultrapure dialysate into the extracorporeal circulation can be used to determine absolute blood volume in clinical practice. The aim of the present study was to evaluate the reproducibility of such measurements. Intra‐individual reproducibility was evaluated in four measurements taken in hourly intervals within the same dialysis treatment. Ten patients were studied. Absolute blood volumes measured at the beginning and after 1 hour of dialysis were significantly different (80.6 ± 14.5 and 63.9 ± 14.3 mL/kg, P < .001) and highly reproducible between the last three measurements (63.9 ± 14.3, 61.4 ± 13.8, and 60.9 ± 13.9 mL/kg, P = n.s.). Measurement of absolute blood volume after 1 hour of treatment is more precise than earlier measurements and might be better suited for guidance of ultrafiltration.