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Evaluation and comparison of polysulfone TS‐UL and PMMA NF‐U dialyzers versus expanded hemodialysis and postdilution hemodiafiltration
Author(s) -
Maduell Francisco,
Broseta José Jesús,
RodríguezEspinosa Diana,
HermidaLama Evelyn,
Rodas Lida María,
Gómez Miquel,
AriasGuillén Marta,
Fontseré Néstor,
Vera Manel,
Rico Nayra
Publication year - 2021
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/aor.13968
Subject(s) - beta 2 microglobulin , myoglobin , albumin , polysulfone , hemodialysis , chemistry , dialysis , creatinine , chromatography , medicine , urology , biochemistry , membrane
Toray has created a new generation of dialyzers, the polysulphone (TS) UL series, and polymethylmethacrylate (PMMA) NF‐U series, which offer enhanced efficacy over the previous TS‐S series and NF‐H series. The aim of this study was to evaluate the safety and efficacy of these dialyzer series versus contrasted expanded hemodialysis (HDx) and postdilution hemodiafiltration (HDF). We conducted a prospective study in 12 patients. Each patient underwent six dialysis sessions: FX80 Cordiax in HD, Toraysulfone TS‐1.8 UL in HD, Theranova 400 in HDx, polymethylmethacrylate (PMMA) NF‐2.1 U in HDF, Toraysulfone TS‐2.1 UL in HDF, and FX80 Cordiax in HDF. The removal ratios (RRs) of urea, creatinine, ß 2 ‐microglobulin, myoglobin, prolactin, α 1 ‐microglobulin, α 1 ‐acid glycoprotein, and albumin were compared intraindividually. Dialysate albumin loss was also measured. The RRs for β 2 ‐microglobulin, myoglobin, prolactin, α 1 ‐microglobulin, and α 1 ‐acid glycoprotein were higher with the TS‐2.1 UL and FX80 Cordiax dialyzers in HDF than those obtained with HD treatments and NF‐2.1 U in HDF. The β 2 ‐microglobulin, myoglobin, and prolactin RRs were also higher with HDx than those obtained with HD treatments. The myoglobin and prolactin RRs were higher with TS‐1.8 UL in HD than those obtained with helixone dialyzers in HD. Dialysate albumin loss was less than 3 g in all situations except in TS‐2.1 UL in HDF. The highest global removal score values were obtained with the TS‐2.1 UL and helixone dialyzers in HDF. Significant differences were found between all study situations. In conclusion, the new generation dialyzers, Toraysulfone TS Series UL and PMMA NF‐U series, show excellent behaviour and tolerance in HD and HDF, representing an upgrade versus their predecessor series. The higher permeability of the TS UL series has been proven with higher efficiency in HD and maximum performance in HDF. The new PMMA NF‐U series allows the use of HDF with good efficiency and complete safety.