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A numerical investigation to evaluate the washout of blood compartments in a total artificial heart
Author(s) -
Luraghi Giulia,
De Gaetano Francesco,
Rodriguez Matas José Félix,
Dubini Gabriele,
Costantino Maria Laura,
De Castilla Hector,
Griffaton Nicolas,
Vignale Davide,
Palmisano Anna,
Gentile Giuseppe,
Esposito Antonio,
Migliavacca Francesco
Publication year - 2020
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/aor.13717
Subject(s) - washout , pulsatile flow , blood flow , ventricle , artificial heart , biomedical engineering , stroke volume , volume (thermodynamics) , heart transplantation , cardiology , transplantation , medicine , ejection fraction , heart failure , physics , quantum mechanics
Total artificial heart (TAH) represents the only valid alternative to heart transplantation, whose number is continuously increasing in recent years. The TAH used in this work, is a biventricular pulsatile, electrically powered, hydraulically actuated flow pump with all components embodied in a single device. One of the major issues for TAHs is the washout capability of the device, strictly correlated with the presence of blood stagnation sites. The aim of this work was to develop a numerical methodology to study the washout coupled with the fluid dynamics evaluation of a total artificial heart under nominal working conditions. The first part of this study focussed on the CT scan analysis of the hybrid membrane kinematics during TAH operation, which was replicated with a fluid‐structure interaction simulation in the second part. The difference in percentage between the in vitro and in silico flow rates and stroke volume is 9.7% and 6.3%, respectively. An injection of contrast blood was simulated, and a good washout performance was observed and quantified with the volume fraction of the contrast blood still in the ventricle. The left chamber of the device showed a superior washout performance, with a contrast volume still inside the device after four washout cycles of 6.2%, with the right chamber showing 15%.