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Multipoint dilution hemofiltration: A new technology for maximum convective clearance
Author(s) -
Mott Vienna L.,
Finley Violet,
Truslow James,
Rossetti Daniel,
Santos Jose,
Gusman Jacob,
Gimbel Alla,
Rogers Miles,
DiBiasio Christopher,
Charest Joseph
Publication year - 2020
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/aor.13640
Subject(s) - filtration (mathematics) , hemofiltration , chromatography , clearance , dilution , chemistry , ultrafiltration (renal) , size exclusion chromatography , free fraction , convection , hemodialysis , surgery , mechanics , biochemistry , plasma protein binding , thermodynamics , medicine , urology , statistics , physics , mathematics , enzyme
Convection‐based renal replacement therapies (RRTs) have the potential to improve patient outcomes when compared to diffusion‐based RRT such as hemodialysis (HD), but have limited clearance rates. We propose and characterize multipoint dilution hemofiltration (MPD‐HF), a purely convective blood purification technology which removes the fundamental filtration limit associated with convective RRT resulting in clearance rates on par with HD. In MPD‐HF, filtration of liquid and solutes occurs along the length of the hollow fibers that convey the blood, and substitution fluid is pushed into the fibers at multiple points along their length. Since multiple filtration and dilution steps are contained within one pass of the blood through the hollow fiber, the fraction of fluid that can be filtered may be increased to allow a high clearance rate that removes a wide range of toxins. In vitro tests yielded an average steady‐state filtrate fraction of 68%, exceeding commercial HDF cartridge filtrate fractions by a factor of approximately 3. The molecular weights of molecules cleared spans up to the cutoff of 66 kDa for albumin.