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Clinical Assessment of Histidine‐Tryptophan‐Ketoglutarate Solution and Modified St. Thomas' Solution in Pediatric Cardiac Surgery of Tetralogy of Fallot
Author(s) -
Wang ZhaoHui,
An Yong,
Du MingCheng,
Qin TingJiang,
Liu YinBei,
Xu HongZhen,
Yang LiQun
Publication year - 2017
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/aor.12771
Subject(s) - medicine , cardiac surgery , perioperative , mechanical ventilation , tetralogy of fallot , intensive care unit , surgery , anesthesia , cardiology , heart disease
The objective of this study is to compare the myocardium protective effect of Bretschneider's histidine‐tryptophan‐ketoglutarate (HTK) solution versus Modified St. Thomas' (STH) solution in pediatric cardiac surgery of Tetralogy of Fallot (TOF). Seventy‐seven pediatric patients of TOF who received the total surgical repair were reviewed, from January 2014 to October 2015. A horizontal comparison between HTK solution and modified STH solution has been made since the HTK solutions were started to be used in our hospital. The patients were divided into the HTK group ( n = 35) and the STH group ( n = 33). The perioperative values of the groups were assessed in this study. The primary endpoints including spontaneous cardiac re‐beating time, intensive care unit (ICU) stay, overall stay, mechanical ventilation postoperation, postoperation stay, overall stay, and perioperative echocardiographic results were analyzed in this study. We found that spontaneous cardiac re‐beating time of the HTK group was significantly shorter than that of the STH group (0.26 min ± 0.56 vs. 1.33 ± 1.02, P < 0.001). There were no significant differences between the two groups in ICU stay ( P = 0.29), postoperative mechanical ventilation time ( P = 0.84), overall stay (0.73); and the mortalities of the two groups were similar (2.9 vs. 3.0%). Aimed at pediatric cardiac surgery of TOF, this study suggests that with similar aorta cross‐clamping time, modified STH solution is as safe as HTK solution.