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Peritoneal Albumin Dialysis as a Novel Approach for Liver Support: Study in a Porcine Model of Acute Hepatic Failure
Author(s) -
Defterevos Georgios,
Nastos Constantinos,
Papalois Apostolos,
Kalimeris Konstantinos,
Margelos Vassileios,
Fragulidis George,
Pafiti Agathi,
Mikrovas Aggeliki,
Nomikos Tzortzis,
Smyrniotis Vassilios,
Arkadopoulos Nikolaos
Publication year - 2016
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/aor.12687
Subject(s) - albumin , peritoneal dialysis , medicine , dialysis , serum albumin , bilirubin , gastroenterology
Artificial liver support gained considerable interest in recent years due to the development of various albumin dialysis systems, which prolong survival of some patients with acute liver failure (ALF). Τhis study aims to examine the role of peritoneal albumin dialysis in a postoperative ALF model. ALF was induced in 14 female Landrace pigs by a combination of major liver resection (70–75% of total parenchyma) and ischemic‐reperfusion injury on the liver remnant. Animals were randomly divided in two groups ( n = 7 each). Both were monitored for 12 h of reperfusion and received peritoneal dialysis for 6 h, beginning 6 h after reperfusion. The albumin group received an albumin‐rich solution and the control group received albumin‐free solution. The control group gradually developed intracranial hypertension, whereas, in the albumin group, rise in the intracranial pressure was substantially attenuated ( P < 0.01, t = 12 h). Albumin‐treated animals had significantly lower levels of ammonia ( P < 0.01), total bile acids ( P < 0.01), free fatty acids ( P < 0.05), lactate ( P < 0.01), and total bilirubin ( P < 0.05). Liver malondialdehyde and protein carbonyl were significantly reduced ( P = 0.007 and P = 0.001 at t = 12 h) after albumin dialysis. Results suggest that this method may become a useful adjunct in the management of ALF, thus, justifying further study.