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Effects of Interaction Between Ventricular Assist Device Assistance and Autoregulated Mock Circulation Including Frank–Starling Mechanism and Baroreflex
Author(s) -
JansenPark SoHyun,
Mahmood Mohammad Nauzef,
Müller Indra,
Turnhoff Lisa Kathrin,
SchmitzRode Thomas,
Steinseifer Ulrich,
Sonntag Simon Johannes
Publication year - 2016
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/aor.12635
Subject(s) - preload , frank–starling law of the heart , afterload , ventricle , circulatory system , cardiology , ventricular assist device , medicine , cardiac output , stroke volume , hemodynamics , baroreflex , venous return curve , contractility , central venous pressure , blood pressure , mean circulatory filling pressure , heart rate , heart failure
A mock heart circulation loop ( MHCL ) is a hydraulic model simulating the human circulatory system. It allows in vitro investigations of the interaction between cardiac assist devices and the human circulatory system. In this study, a preload sensitive MHCL , the MHCL AUTO , was developed to investigate the interaction between the left ventricle and left ventricular assist devices ( LVADs ). The F rank– S tarling mechanism was modeled by regulating the stroke volume ( SV ) based on the measured mean diastolic left atrial pressure ( MLAP diast ). The baroreflex autoregulation mechanism was implemented to maintain a constant mean aortic pressure ( MAP ) by varying ventricular contractility ( E max ), heart rate ( HR ), afterload/systemic vascular resistance ( SVR ) and unstressed venous volume ( UVV ). The DP3 blood pump ( M edos M edizintechnik GmbH ) was used to simulate the LVAD . Characteristic parameters were measured in pathological conditions both with and without LVAD to assess the hemodynamic effect of LVAD on the MHCL AUTO . The results obtained from the MHCL AUTO show a high correlation to literature data. The study demonstrates the possibility of using the MHCL AUTO as a research tool to better understand the physiological interactions between cardiac implants and human circulation.