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B ‐Type Natriuretic Peptide Levels Predict Ventricular Arrhythmia Post Left Ventricular Assist Device Implantation
Author(s) -
Hellman Yaron,
Malik Adnan S.,
Lin Hongbo,
Shen Changyu,
Wang IWen,
Wozniak Thomas C.,
Hashmi Zubair A.,
Pickrell Jeanette,
Jani Milena,
Caccamo Marco A.,
GradusPizlo Irmina,
Hadi Azam
Publication year - 2015
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/aor.12486
Subject(s) - medicine , cardiology , ventricular assist device , ventricular fibrillation , heart failure , ventricular tachycardia , natriuretic peptide , myocardial infarction , incidence (geometry) , retrospective cohort study , brain natriuretic peptide , logistic regression , physics , optics
B ‐type natriuretic peptide ( BNP ) levels have been shown to predict ventricular arrhythmia ( VA ) and sudden death in patients with heart failure. We sought to determine whether BNP levels before left ventricular assist device ( LVAD ) implantation can predict VA post LVAD implantation in advanced heart failure patients. We conducted a retrospective study consisting of patients who underwent LVAD implantation in our institution during the period of M ay 2009– M arch 2013. The study was limited to patients receiving a H eart M ate II or H eart W are LVAD . Acute myocardial infarction patients were excluded. We compared between the patients who developed VA within 15 days post LVAD implantation to the patients without VA . A total of 85 patients underwent LVAD implantation during the study period. Eleven patients were excluded (five acute MI , four without BNP measurements, and two discharged earlier than 13 days post LVAD implantation). The incidence of VA was 31%, with 91% ventricular tachycardia ( VT ) and 9% ventricular fibrillation. BNP remained the single most powerful predictor of VA even after adjustment for other borderline significant factors in a multivariate logistic regression model ( P < 0.05). BNP levels are a strong predictor of VA post LVAD implantation, surpassing previously described risk factors such as age and VT in the past.