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Tissue Engineering Strategies as Tools for Personalized Meningioma Treatment
Author(s) -
Ferroni Letizia,
Della Puppa Alessandro,
D'Avella Domenico,
Isola Maurizio,
Scienza Renato,
Gardin Chiara,
Zavan Barbara
Publication year - 2015
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/aor.12483
Subject(s) - pharmacogenomics , malignancy , personalized medicine , meningioma , computational biology , comparative genomic hybridization , skin cancer , in vitro , cancer , medicine , bioinformatics , pathology , biology , genome , genetics , gene
Pharmacogenomics, the science of how genetic makeup influences an individual's reaction to drugs, is an innovative tool for providing critical insights into how a patient will respond to a particular treatment. In the present work, we constructed cancer‐like tissues to be used as tools for determining the most effective drug for an individual patient. Using tissue engineering strategies, we generated two different solid tumor‐like tissues in vitro, a neuronal tumor (meningioma) and a nonmelanoma skin cancer. Samples were tested by both histological and genetic approaches (using a comparative genomic hybridization array, and the relative W orld H ealth O rganization classification of the samples was compared with the results obtained by the molecular analyses. Our data confirmed the ability of the cells to maintain their phenotype in three‐dimensional scaffolds as well as the strong relationship between chromosomal alterations and histological malignancy grades. We then validated the in vitro construction of tumor‐like tissues as a potential tool for developing personalized drug treatments.