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Carbon Dioxide and Acetate‐Free Biofiltration: A Relationship to be Investigated
Author(s) -
Marano Marco,
D'Amato Anna,
Patriarca Alessandro,
Di Nuzzi Luigi Michele,
Giordano Gelsomina,
Iulianiello Giuseppe
Publication year - 2015
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/aor.12477
Subject(s) - dialysis , hemodialysis , bicarbonate , carbon dioxide , pco2 , extracorporeal , medicine , biofilter , chemistry , waste management , organic chemistry , engineering
As the name reveals, acetate‐free biofiltration ( AFB ) is featured by lack of acetate and this would seem to allow better hemodynamic stability. However, AFB also has a unique characteristic of carbon dioxide ( CO 2 )‐free dialysate, whereas all other modern dialysis techniques imply an overload of CO 2 from dialysate to the patient. This notwithstanding the role of CO 2 in tolerance to dialysis treatment, both AFB and all other dialysis techniques seem not investigated in due depth. Specifically, the amount of CO 2 coming back to the patient's bloodstream during AFB and bicarbonate dialysis ( BD ) is unknown. We measured partial pressure of CO 2 (p CO 2 ) in blood samples withdrawn from the venous line of the extracorporeal circuit during BD and subsequently during AFB in 22 stable chronic hemodialysis outpatients. The amount of CO 2 coming back to the patient's bloodstream is higher in BD (59.1 ± 4.0 mmol/L) than in AFB (4 2.8 ± 4.5 mmol/L, P < 0.0001). Such difference exceeds 30%. Moreover, shifting from BD to AFB shows, notably for each patient, the reduction of p CO 2 toward physiological values. BD implies CO 2 overload from dialysate, whereas AFB does not. Further studies are required to evaluate if AFB would be the most appropriate dialysis technique in patients affected by chronic, but especially acute, lung diseases.