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The Relationship Between R ‐Wave Magnitude and Ventricular Volume During Continuous Left Ventricular Assist Device Assistance: Experimental Study
Author(s) -
Fresiello Libera,
Trivella Maria Giovanna,
Di Molfetta Arianna,
Ferrari Gianfranco,
Bernini Fabio,
Meste Olivier
Publication year - 2015
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/aor.12407
Subject(s) - ventricle , ventricular assist device , cardiology , medicine , volume (thermodynamics) , qrs complex , centrifugal pump , heart failure , physics , mechanics , quantum mechanics , impeller
The current use of left ventricular assist devices ( LVADs ) as destination therapy is associated with the clinical need of monitoring patient–pump interaction. To this aim, the present work investigated the possibility of getting useful information about the status of the assisted left ventricle using electrocardiographic ( ECG ) data. A total of six animals, undergoing G yro C entrifugal P ump 2 implantation (a new version of G yro C entrifugal P ump C1E 3 [Kyocera Corporation, Kyoto, Japan]) and C ircu L ite S ynergy Mi cropump (CircuLite, Inc., Saddlebrooke, NJ, USA) in atrio‐aortic connection, were analyzed. Data refer to different LVAD speeds with consequently different levels of ventricular unloading. From ECG signal, the R wave peak was individuated together with the corresponding left ventricular volume. Then on both signals, a moving average analysis was performed to reduce the effect of the ventilation. A regression and correlation analysis performed on the two resulting signals evidenced that the R wave peak and the ventricular volume are strictly related. Specifically, any change of LVAD speed, inducing a change in ventricular volume, is associated with a change in R wave peak value. The present work is a first step in investigating the usefulness of the ECG signal during LVAD therapy, for the monitoring of mechanical parameters of the heart such as the ventricular volumes. The correlation found between the ECG and the ventricular volume can be a promising starting point for possible future noninvasive LVAD patient monitoring.