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Similar Cerebral Protective Effectiveness of Antegrade and Retrograde Cerebral Perfusion During Deep Hypothermic Circulatory Arrest in Aortic Surgery: A Meta‐Analysis of 7023 Patients
Author(s) -
Guo Shasha,
Sun Yanhua,
Ji Bingyang,
Liu Jinping,
Wang Guyan,
Zheng Zhe
Publication year - 2015
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/aor.12376
Subject(s) - deep hypothermic circulatory arrest , medicine , cerebral perfusion pressure , extracorporeal circulation , cardiopulmonary bypass , cardiac surgery , cardiology , stroke (engine) , anesthesia , clinical endpoint , meta analysis , perfusion , surgery , randomized controlled trial , mechanical engineering , engineering
In aortic arch surgery, deep hypothermic circulatory arrest ( DHCA ) combined with cerebral perfusion is employed worldwide as a routine practice. Even though antegrade cerebral perfusion ( ACP ) is more widely used than retrograde cerebral perfusion ( RCP ), the difference in benefit and risk between ACP and RCP during DHCA is uncertain. The purpose of this meta‐analysis is to compare neurologic outcomes and early mortality between ACP and RCP in patients who underwent aortic surgery during DHCA . P ub M ed, EMBASE , and the C ochrane L ibrary were searched using the key words “antegrade,” “retrograde,” “cerebral perfusion,” “cardiopulmonary bypass,” “extracorporeal circulation,” and “cardiac surgery” for studies reporting on clinical endpoints including early mortality, stroke, temporary neurologic dysfunction ( TND ), and permanent neurologic dysfunction ( PND ) in aortic surgery requiring DHCA with ACP or RCP . Heterogeneity was analyzed with the C ochrane Q statistic and I 2 statistic. Publication bias was tested with B egg's funnel plot and E gger's test. Thirty‐four studies were included in this meta‐analysis, with 4262 patients undergoing DHCA + ACP and 2761 undergoing DHCA + RCP . The overall pooled relative risk for TND was 0.722 (95% CI = [0.579, 0.900]), and the z ‐score for overall effect was 2.9 ( P = 0.004). There was low heterogeneity ( I 2 = 18.7%). The analysis showed that patients undergoing DHCA + ACP had better outcomes than those undergoing DHCA + RCP in terms of TND , while there were no significant differences between groups in terms of PND , stroke, and early mortality. This meta‐analysis indicates that DHCA + ACP has an advantage over DHCA + RCP in terms of TND , while the two methods show similar results in terms of PND , early mortality, and stroke.