Premium
Development of Dual‐Setting Calcium Phosphate Cement Using Absorbable Polymer
Author(s) -
Thürmer Mônica Beatriz,
Diehl Carlos Eduardo,
Brum Fábio José Bento,
Santos Luís Alberto
Publication year - 2013
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/aor.12236
Subject(s) - compressive strength , simulated body fluid , ammonium persulfate , materials science , cement , self healing hydrogels , composite material , biomaterial , scanning electron microscope , acrylic acid , polymer , ammonium phosphate , composite number , chemical engineering , phosphate , chemistry , polymer chemistry , polymerization , copolymer , organic chemistry , nanotechnology , fertilizer , engineering
Calcium phosphate cements used as bone substitutes generally have low mechanical strength compared with the bones of the human body. To solve these needs, we have incorporated hydrogels in the manufacture of samples made of alpha‐tricalcium phosphate (α‐ TCP ) cement, developing a system of dual‐setting cement. This study aimed to produce composite materials by combining α‐ TCP powder and hydrogels. The composites were prepared using the synthesized powder and four different formulations of hydrogels, using either poly( N ‐vinyl‐2‐pyrrolidone) or poly( N ‐vinyl‐2‐pyrrolidone–co‐acrylic acid), with either azobisisobutyronitrile or ammonium persulfate as initiator. The properties of all composites were evaluated through measuring compressive strength and apparent density and through X‐ray diffraction and scanning electron microscopy. The composites showed compressive strengths of around 24 MPa. Soaking the samples in simulated body fluid formed a layer of hydroxyapatite‐like crystals on the surface of some samples, showing the bioactivity of the newly developed cements and their potential use as biomaterial.