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Exercise Hemodynamics During Extended Continuous Flow Left Ventricular Assist Device Support: The Response of Systemic Cardiovascular Parameters and Pump Performance
Author(s) -
Martina Jerson,
Jonge Nicolaas,
Rutten Marcel,
Kirkels J. Hans,
Klöpping Corinne,
Rodermans Ben,
Sukkel Eveline,
Hulstein Nelienke,
Mol Bas,
Lahpor Jaap
Publication year - 2013
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/aor.12151
Subject(s) - medicine , hemodynamics , cardiology , vascular resistance , blood pressure , heart rate , cardiac output , blood flow , continuous flow , ventricular assist device , heart failure , physics , mechanics
Abstract Patients on continuous flow left ventricular assist devices ( cf‐LVADs ) are able to return to an active lifestyle and perform all sorts of physical activities. This study aims to evaluate exercise hemodynamics in patients with a H eart M ate II cf‐LVAD ( HM II ). Thirty (30) patients underwent a bicycle exercise test. Along with exercise capacity, systemic cardiovascular responses and pump performance were evaluated at 6 and 12 months after HM II implantation. From rest to maximum exercise, heart rate increased from 87 ± 14 to 140 ± 32 beats/minute (bpm) ( P < 0.01), while systolic arterial blood pressure increased from 93 ± 12 to 116 ± 21 mm Hg ( P < 0.01). Total cardiac output ( TCO ) increased from 4.1 ± 1.1 to 8.5 ± 2.8 L/min ( P < 0.01) while pump flow increased less, from 5.1 ± 0.7 to 6.4 ± 0.6 L/min ( P < 0.01). Systemic vascular resistance ( SVR ) decreased from 1776 ± 750 to 1013 ± 383 dynes.s/cm 5 ( P < 0.001) and showed the strongest correlation with TCO (r = −0.72; P < 0.01). Exercise capacity was affected by older age, while blood pressure increased significantly in men compared with women. Exercise capacity remained consistent at 6 and 12 months after HM II implantation, 51% ± 13% and 52% ± 13% of predicted VO 2 max for normal subjects corrected for age and gender. In conclusion, pump flow of the HM II may contribute partially to TCO during exercise, while SVR was the strongest determinant of TCO .