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Miniaturization: The Clue to Clinical Application of the Artificial Placenta
Author(s) -
Schoberer Mark,
Arens Jutta,
Erben Aileen,
Ophelders Daan,
Jellema Reint K.,
Kramer Boris W.,
Bruse Jan L.,
Brouwer Petra,
Schmitz–Rode Thomas,
Steinseifer Ulrich,
Orlikowsky Thorsten
Publication year - 2014
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/aor.12146
Subject(s) - oxygenator , medicine , intensive care medicine , extracorporeal circulation , artificial lung , surgery , cardiopulmonary bypass , anesthesia
The artificial placenta as a fascinating treatment alternative for neonatal lung failure has been the subject of clinical research for over 50 years. Pumpless systems have been in use since 1986. However, inappropriate dimensioning of commercially available oxygenators has wasted some of the theoretical advantages of this concept. Disproportional shunt fractions can cause congestive heart failure. Blood priming of large oxygenators and circuits dilutes fetal hemoglobin (as the superior oxygen carrier), is potentially infectious, and causes inflammatory reactions. Flow demands of large extracorporeal circuits require cannula sizes that are not appropriate for use in preterm infants. NeonatOx, a tailored low‐volume oxygenator for this purpose, has proven the feasibility of this principle before. We now report the advances in biological performance of a refined version of this specialized oxygenator.