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Low‐Output Is Not the Cause of Death of Neonatal Piglets Early After Cardiopulmonary Bypass
Author(s) -
Tirilomis Theodor,
Bensch Marc,
Nolte Lars,
Steinke Katja,
Schoendube Friedrich A.
Publication year - 2013
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/aor.12030
Subject(s) - cardiopulmonary bypass , medicine , median sternotomy , anesthesia , inotrope , hemodynamics , contractility , ascending aorta , heart rate , cardiology , aorta , blood pressure
The mortality rate of neonatal piglets after heart surgery is high. Searching for a possible explanation for the death of neonatal piglets early after cardiopulmonary bypass, we analyzed hemodynamic parameters regarding survival and non‐survival. Initially, 10 neonatal piglets (younger than 7 days) were connected to cardiopulmonary bypass ( CPB ). The mean body weight was 2.98 ± 0.44 kg. Exposure of the heart was performed through a median sternotomy. After connection to the CPB , the piglets were cooled to 32° C core temperature before the ascending aorta was cross‐clamped and the heart arrested (90 min). Thereafter, piglets were re‐warmed to 37° C and separated from CPB . During follow‐up, the piglets did not receive inotropic support or vasopressors. Piglets who survived at least 2 h after termination of CPB were included in the study for further data analysis ( n = 9). Five piglets died 2.5 to 4.0 h (median: 3.5 h) after CPB ; these piglets formed the non‐survivors group. Four animals survived the complete follow‐up of 6 h after CPB and formed the survivors group. Regarding contractility ( dP / dt max , dP / dt max / P , and wall thickening) there were not statistically significant differences between the groups. Non‐survivors showed prolonged decrease of mean arterial pressure of more than 20% of baseline values, corresponding with a value of below 30 mm H g. In conclusion, the death of neonatal piglets early after cardiopulmonary bypass was not determined by low output.