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New Generation Extracorporeal Membrane Oxygenation With M ed T ech M ag‐ L ev, a Single‐Use, Magnetically Levitated, Centrifugal Blood Pump: Preclinical Evaluation in Calves
Author(s) -
Fujiwara Tatsuki,
Nagaoka Eiki,
Watanabe Taiju,
Miyagi Naoto,
Kitao Takashi,
Sakota Daisuke,
Mamiya Taichi,
Shinshi Tadahiko,
Arai Hirokuni,
Takatani Setsuo
Publication year - 2013
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/aor.12006
Subject(s) - extracorporeal membrane oxygenation , chemistry , membrane , biochemistry , medicine , anesthesia
Abstract We have evaluated the feasibility of a newly developed single‐use, magnetically levitated centrifugal blood pump, M ed T ech M ag‐ L ev, in a 3‐week extracorporeal membrane oxygenation ( ECMO ) study in calves against a M edtronic B io‐ P ump BPX ‐80. A heparin‐ and silicone‐coated polypropylene membrane oxygenator MERA NHP E xcelung NSH ‐ R was employed as an oxygenator. Six healthy male H olstein calves with body weights of about 100 kg were divided into two groups, four in the M ed T ech group and two in the B io‐ P ump group. Under general anesthesia, the blood pump and oxygenator were inserted extracorporeally between the main pulmonary artery and the descending aorta via a fifth left thoracotomy. Postoperatively, both the pump and oxygen flow rates were controlled at 3 L /min. Heparin was continuously infused to maintain the activated clotting time at 200–240 s. All the M ed T ech ECMO calves completed the study duration. However, the B io‐ P ump ECMO calves were terminated on postoperative days 7 and 10 because of severe hemolysis and thrombus formation. At the start of the M ed T ech ECMO , the pressure drop across the oxygenator was about 25 mm H g with the pump operated at 2800 rpm and delivering 3 L /min flow. The PO 2 of the oxygenator outlet was higher than 400 mm H g with the PCO 2 below 45 mm H g. H emolysis and thrombus were not seen in the M ed T ech ECMO circuits (plasma‐free hemoglobin [ PFH ] < 5 mg/d L ), while severe hemolysis ( PFH > 20 mg/d L ) and large thrombus were observed in the B io‐ P ump ECMO circuits. Plasma leakage from the oxygenator did not occur in any ECMO circuits. Three‐week cardiopulmonary support was performed successfully with the M ed T ech ECMO without circuit exchanges. The M ed T ech M ag‐ L ev could help extend the durability of ECMO circuits by the improved biocompatible performances.