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Development of a Novel Emergency Hemostatic Kit for Severe Hemorrhage
Author(s) -
Hattori Hidemi,
Amano Yoshiko,
Nogami Yashiro,
Kawakami Masahiro,
Yura Hirofumi,
Ishihara Masayuki
Publication year - 2013
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/aor.12004
Subject(s) - irradiation , hemostasis , chemistry , biomedical engineering , surgery , medicine , nuclear physics , physics
Photocrosslinkable chitosan ( Az ‐ CH ‐ LA ) contains lactose moieties and photoreactive azide groups, and its viscous solution forms an insoluble hydrogel on exposure to UV irradiation. We previously developed an emergency hemostatic kit using the Az ‐ CH ‐ LA solution, calcium alginate, and a UV irradiation apparatus. However, a suitable UV irradiation apparatus is required to effectively convert the Az ‐ CH ‐ LA solution into a hydrogel, and power supply to use the UV irradiation apparatus may not always be available in a disaster area or battlefield. To address this problem, we produced a portable, battery‐powered UV irradiation apparatus constituting a novel hemostatic kit for severe hemorrhage. When the hemostatic kit using the UV irradiation apparatus was examined using a rat model of severe hemorrhage, the survival rate increased up to 73%. Hematological values as markers of hemorrhage did not change significantly over the first 3 days. In this study, we describe the characteristics of a portable UV irradiation apparatus and its use in an emergency hemostatic kit prepared using Az ‐ CH ‐ LA and calcium alginate for severe hemorrhage.