Open AccessPROPHYLACTIC USE OF 15(S)15 METHYL PGF 2 α , BY INTRAMUSCULAR ROUTE — A CONTROLLED CLINICAL TRIAL
Author(s) -
Anjaneyulu R,
PK Devi,
Jain S,
CR Kanthamani,
Vijaya R,
KS Raghavan
Publication year - 1988
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.1988.67.s145.9
Subject(s) - ergometrine , medicine , blood loss , anesthesia , third stage , intramuscular injection , surgery , training (meteorology) , physics , meteorology
In a multicentre study the safety and efficacy of 125 µ g intramuscular injection of 15(S)15 methyl PGF 2 α , (Prostin 15M, Upjohn) was compared with ergometrine and controls who did not receive any oxytocic for prophylactic control of postpartum bleeding. The study included 441 patients. The duration of third stage was shortened to 6.1 minutes following ergometrine and to 3.5 minutes following Prostin 15M compared to 7.6 minutes in the control subjects. Similarly the blood loss during third stage was less (95.2 ml) in Prostin 15M treated group compared to the untreated control group (233.2 ml). Prostin 15M, when used prophylactically, was also better than ergometrine (154.0 ml) in controlling the blood loss during third stage of labour in normal vaginal delivery.