Open AccessINTRAMUSCULAR 15(S)15 METHYL PGF 2 α FOR PREOPERATIVE CERVICAL DILATATION DURING FIRST TRIMESTER
Author(s) -
Devi PK,
Jain S,
CR Kanthamani,
KS Raghavan
Publication year - 1988
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.1988.67.s145.55
Subject(s) - medicine , cervical dilatation , vacuum aspiration , cervical canal , vomiting , pregnancy , significant difference , surgery , anesthesia , gynecology , cervix , research methodology , family planning , population , environmental health , cancer , biology , genetics
The effect of single intramuscular injection of 15(S)15 methyl PGF 2 α . (Prostin 15M, Upjohn) on cervical dilatation was tried in women during first trimester pregnancy. Prostin 15M was given at a dose of 250 µ g. Three hours later the cervical dilatation and uterine consistency were assessed and recorded, prior to vacuum aspiration. The control group consisted of women who did not receive any drugs for cervical dilatation. The mean cervical dilatation in Prostin 15M group was 9.7 ± 2.3 (S.D.) mm compared to 3.4 ± 1.5 (S.D.) mm in the control group. This difference was statistically significant (p <0.01). Vomiting was experienced by 18.6% and diarrhea by 20.9% of the patients. There was no significant difference in the blood loss between the Prostin 15M group and the control group.