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This study aimed to investigate whether maternal blood lipid levels during early pregnancy are associated with the occurrence of congenital heart disease (CHD) in their offspring.    Material and methods  In this single‐center case–control study, mothers of offspring with CHD ( n  = 230) and without CHD ( n  = 381) were included. Maternal lipid levels were determined on fasting blood samples taken in the first trimester. Relevant demographic and clinical data were extracted from the medical records. Maternal lipid profile was compared between the two groups, and regression analysis was performed to evaluate the association between lipid profile and CHD risk in offspring.    Results  Compared with the control group, levels of triglyceride, apolipoprotein‐A1, and apolipoprotein‐B in early pregnancy were significantly higher in the CHD group. Multivariate analyses showed that triglyceride (odds ratio [OR] 2.46, 95% CI 1.62–3.73,  p  < 0.01), total/high‐density lipoprotein cholesterol (OR 2.10, 95% CI 1.07–4.13,  p  = 0.03), and apolipoprotein‐A1 (OR 2.73, 95% CI 1.16–6.40,  p  = 0.02) were positively associated with CHD risk in offspring.    Conclusions  Elevated maternal lipid profile was associated with increased risk of CHD in offspring.

High maternal blood lipid levels during early pregnancy are associated with increased risk of congenital heart disease in offspring