Open AccessVolume blood flow‐based indices of fetal brain sparing in the second half of pregnancy: A longitudinal study
Author(s) -
Stefopoulou Maria,
Johnson Jonas,
Wilsgaard Tom,
Lindgren Peter,
Herling Lotta,
Kiserud Torvid,
Acharya Ganesh
Publication year - 2020
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.13950
Subject(s) - medicine , gestational age , cerebral blood flow , cardiology , pregnancy , obstetrics , middle cerebral artery , fetus , blood flow , nuclear medicine , ischemia , genetics , biology
Abstract Introduction Cerebroplacental ratio (CPR) and umbilicocerebral ratio (UCR) are clinically used as a measure of fetal brain sparing. These are calculated as the ratios between the pulsatility indices (PIs) of middle cerebral (MCA) and umbilical (UA) arteries, and are an indirect representation of the balance between cerebral and placental perfusion. Volume blood flow (Q)‐based ratios, ie Q‐CPR or Q‐UCR, would directly reflect the distribution of fetal cardiac output to the placenta and brain. Thus, we aimed to determine the development pattern of Q‐CPR and Q‐UCR during the second half of pregnancy, construct reference intervals, and evaluate their association with CPR and UCR. Material and methods In a longitudinal cohort study of low‐risk pregnancies, the inner diameter of the fetal superior vena cava (SVC) and umbilical vein (UV) was measured and velocity waveforms were obtained from the MCA, UA, UV and SVC using ultrasound at approximately 4‐weekly intervals from 20 to 41 weeks. The CPR was calculated as PI MCA /PI UA and the inverse ratio was the UCR. Cerebral and placental blood flows were estimated as the product of mean velocity and cross‐sectional area of the SVC and UV, respectively. Q‐CPR was calculated as Q SVC /Q UV and the inverse as the Q‐UCR. Gestational age‐specific reference intervals were calculated and associations between variables were tested using multilevel regression modeling. Results Longitudinal reference intervals of Q‐CPR and Q‐UCR were established based on 471 paired measurements of Q SVC and Q UV obtained serially from 134 singleton pregnancies. The mean Q‐CPR increased from 0.4 to 0.8 during the second half of pregnancy and Q‐UCR declined from 2.5 to 1.3, while the CPR and UCR had U‐shaped curves but in opposite directions. No significant correlation was found between CPR and Q‐CPR (R = 0.10; P = .051), or UCR and Q‐UCR (R = 0.09; P = .11), and the agreement between PI‐based and Q‐based indices of fetal brain sparing was poor. Conclusions Indices of fetal brain sparing based on placental and cerebral volume blood flow differ from those calculated from UA and MCA PIs. They correlated poorly with conventional CPR and UCR, indicating that they may provide additional/different physiological information. Reference values of Q‐CPR and Q‐UCR established here can be useful to investigate their clinical value further.