Open AccessRisk of preterm birth, low birthweight and small‐for‐gestational‐age infants in pregnancies with adenomyosis: A cohort study of the Japan Environment and Children's Study
Author(s) -
Yamaguchi Akiko,
Kyozuka Hyo,
Fujimori Keiya,
Hosoya Mitsuaki,
Yasumura Seiji,
Yokoyama Tadahiko,
Sato Akiko,
Hashimoto Koichi
Publication year - 2019
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.13498
Subject(s) - medicine , obstetrics , pregnancy , odds ratio , gestational age , small for gestational age , adenomyosis , cohort study , body mass index , low birth weight , premature birth , birth weight , gynecology , endometriosis , genetics , biology
This study evaluated the risk of preterm birth, low birthweight and small‐for‐gestational‐age neonates born to mothers with adenomyosis during pregnancy. Material and methods We used the results of a Japanese nationwide prospective birth cohort study, identifying 93 668 singleton deliveries from 2011 to 2014. We identified 314 pregnancies with adenomyosis using self‐reported questionnaires. Multiple logistic regression analyses were conducted to examine whether adenomyosis was associated with adverse pregnancy outcome. Maternal age, smoking status, method of conception, history of parity, fibroids, endometriosis and body mass index before pregnancy were analyzed as confounding factors. Results Multiple logistic regression analysis showed that pregnancy with adenomyosis was a risk factor for preterm birth at less than 37 weeks (adjusted odds ratio [ aOR : 2.49, 95% confidence interval [ CI] 1.89‐3.41), preterm birth at less than 34 weeks ( aOR 1.91, 95% CI 1.02‐3.55), low birthweight <2500 g ( aOR 1.83, 95% CI 1.36‐2.45), low birthweight <1500 g ( aOR 2.39, 95% CI 1.20‐4.77) and small‐for‐gestational‐age neonates ( aOR 1.68, 95% CI 1.13‐2.51). Conclusions This study found that pregnancy with adenomyosis was associated with preterm birth, low birthweight and small‐for‐gestational‐age neonates.