Open AccessMortality and causes of death among women with a history of placental abruption
Author(s) -
Riihimäki Outi,
Paavonen Jorma,
Luukkaala Tiina,
Gissler Mika,
Metsäranta Marjo,
Andersson Sture,
Nuutila Mika,
Pukkala Eero,
Melin Johanna,
Tikkanen Minna
Publication year - 2017
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.13212
Subject(s) - medicine , placental abruption , obstetrics , placenta diseases , fetal death , pregnancy , perinatal mortality , gynecology , placenta , gestation , fetus , genetics , biology
Women with a history of placental abruption have an increased later morbidity, but not much is known of the later mortality. Material and methods Data on women with placental abruption (index cohort) between 1969 and 2005 ( n = 7805) were collected from the Finnish Hospital Discharge Register and the Finnish Medical Birth Register. A matched reference cohort consisted of women without placental abruption ( n = 23 523). The causes of death were retrieved from the Cause‐of‐Death Register. Cause‐specific mortality was compared by hazard ratios (HR). Standardized mortality ratios were calculated to compare both cohorts with the general female population. The main outcome measure was subsequent mortality. Results By the end of 2013 there were 395 deaths in the index cohort and 863 deaths in the reference cohort. The overall mortality was increased in the index cohort compared with the reference cohort [HR 1.39, 95% confidence interval (CI) 1.24–1.57]. The index cohort had an increased risk of death from respiratory tract malignancies (HR 1.72, 95% CI 1.05–2.82), alcohol‐related causes (HR 1.84, 95% CI 1.25–2.72), and external causes (HR 1.63, 95% CI 1.19–2.22), especially suicide (HR 1.71, 95% CI 1.07–2.74). The mortality from cardiovascular diseases did not differ. The standardized mortality ratio was increased in the index cohort compared with the general Finnish female population (HR 1.13, 95% CI 1.02–1.24), especially for respiratory tract malignancies (HR 1.79, 95% CI 1.16–2.64). The index cohort women tended to die younger than referent women ( p < 0.001). Conclusions Overall mortality among women with a history of placental abruption is increased. These women tend to die younger than referent women do.