Open AccessUse of hormone replacement therapy after risk‐reducing salpingo‐oophorectomy
Author(s) -
Johansen Nora,
Liavaag Astrid H.,
Iversen OleErik,
Dørum Anne,
Braaten Tonje,
Michelsen Trond M.
Publication year - 2017
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.13120
Subject(s) - medicine , hormone replacement therapy (female to male) , odds ratio , menopause , breast cancer , gynecology , logistic regression , confidence interval , oophorectomy , obstetrics , ovarian cancer , estrogen , cancer , hysterectomy , surgery , testosterone (patch)
After premenopausal risk‐reducing salpingo‐oophorectomy ( RRSO ) to prevent ovarian cancer, the non‐cancer‐related morbidity and mortality may be increased if sex hormones are not replaced. Several guidelines recommend systemic hormone replacement therapy ( HRT ) to these women until the expected age of menopause. We aimed to study the use of HRT after RRSO . Material and methods Participants were 324 women after RRSO and 11 160 postmenopausal controls. A subsample of 950 controls had undergone bilateral salpingo‐oophorectomy ( BSO ). All participants completed the same questionnaire regarding HRT use. We compared HRT use in the RRSO group with the BSO controls using logistic regression. Results Among the women aged ≤52 years without a history of breast cancer, 51.7% of the RRSO group and 48.7% of the BSO controls reported current use of systemic HRT (odds ratio 1.13, 95% confidence interval 0.72–1.76). Among the HRT users, systemic estrogen was used by 35.1% and 58.7% in the RRSO and BSO control groups, respectively ( p = 0.001). Among the women aged >52 years, 16.8% of the RRSO group and 38.4% of the BSO controls ( p < 0.001) used systemic HRT . Conclusions Among the RRSO women and BSO controls ≤52 years old without a history of breast cancer, relatively few were current users. If there are no contraindications, these women would benefit from systemic HRT . Additionally, almost 40% of the BSO controls >52 years used systemic HRT . Doctors should be aware of this practice and prescribe systemic HRT when indicated.