Open AccessHuman papillomavirus test with cytology triage in organized screening for cervical cancer
Author(s) -
Veijalainen Olga,
Kares Saara,
Kujala Paula,
Tirkkonen Mika,
Vuento Risto,
Kholová Ivana,
Luukkaala Tiina,
Osuala Veronika,
Mäenpää Johanna
Publication year - 2016
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.13013
Subject(s) - medicine , triage , cervical cancer , human papillomavirus , cytology , colposcopy , test (biology) , gynecology , pap test , papillomaviridae , cervical cancer screening , cancer , obstetrics , pathology , medical emergency , paleontology , biology
In randomized studies, testing for high‐risk ( HR ) human papillomavirus (hrHPV) has been more sensitive than conventional cytology in detecting cervical intraepithelial neoplasia ( CIN ). The aim of this study was to evaluate the performance of HPV testing in the setting of an organized routine screening program. Material and methods Since 2012, 35‐ to 60‐year‐old women living in the city of Tampere have been screened with the Abbott RealTime hrHPV test. HPV ‐negative women are referred to the next screening round in five years. HPV ‐positive women are triaged with conventional cytology, and women with at least low‐grade squamous intraepithelial lesion ( LSIL + ) are referred to colposcopy. The remaining HPV ‐positive women are referred for re‐testing after 12 months, and then all HPV ‐positive women are referred to colposcopy. The data from the last cohort with cytological screening (screened in 2011) is presented for comparison. Results A total 5637 (70%) women attended the first round of HPV screening, and 369 were HPV ‐positive. Of them, 54 women LSIL + were referred to colposcopy, resulting in 16 CIN 2 + lesions found. Of the remaining HPV ‐positive women, 66% were still positive one year later, and were referred to colposcopy, with 18 additional CIN 2 + lesions found. The attendance rate to the last round of cytological screening was 71% (5814 women). Sixty‐four women with LSIL + cytology were referred to colposcopy, and 11 CIN 2 + lesions were found. Of the 777 women with borderline cytology and scheduled for reflex screening in the following year, 109 (19%) had ASC ‐ US + , and 57 underwent colposcopy, resulting in six additional CIN 2 + lesions found. The total detection rate of CIN 2 + was significantly higher in the HPV ‐screened cohort (6.0/1000 vs. 2.9/1000, p = 0.015). However, the total colposcopy rate was 4% vs. 2%, respectively ( p < 0.001). Conclusion Human papillomavirus testing also seems to be more sensitive than cytology in detecting CIN 2 + lesions in the setting of a routine organized screening program, besides in the context of randomized trials. The problem of an increased colposcopy rate needs to be addressed in the future.