Open AccessThe prognostic value of the miR‐200 family in ovarian cancer: a meta‐analysis
Author(s) -
Shi Can,
Zhang Zhenyu
Publication year - 2016
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.12883
Subject(s) - hazard ratio , confidence interval , medicine , oncology , ovarian cancer , proportional hazards model , survival analysis , gynecology , cancer
To assess the association between miR‐200 family expression and overall survival/progression‐free survival in women with ovarian cancer. Material and methods A systematic literature search, up to September 2015, in PubMed, EMBASE and Cochrane Library was performed to identify articles that assessed the association between miR‐200 family expression and the survival of women with ovarian cancer. Summary hazard ratios and 95% confidence interval were calculated to estimate the effect. Results A total of seven articles, consisting of 553 women, were included in this meta‐analysis. Overall, significantly improved overall survival/progression‐free survival were observed with higher expression of the miR‐200 family in women with ovarian cancer (overall survival, hazard ratio = 0.34, 95% confidence interval 0.20–0.58; progression‐free survival, hazard ratio = 0.64, 95% confidence interval 0.50–0.82). Subgroup analysis revealed that there was a significant association between enhanced expression of the miR‐200c and improved overall survival (hazard ratio = 0.20, 95% confidence interval 0.10–0.42) and progression‐free survival (hazard ratio = 0.30, 95% confidence interval 0.11–0.81). Moreover, in the Asian population, a significant association was found between higher expression of the miR‐200 family and improved overall survival (hazard ratio = 0.20, 95% confidence interval 0.09–0.45). Conclusion High expression of miR‐200c may predict improved survival in women with ovarian cancer and high expression of the miR‐200 family significantly improves overall survival for Asian women.