Open AccessObstetrical outcome in women with urinary tract infections in childhood
Author(s) -
Gebäck Carin,
Hansson Sverker,
Martinell Jeanette,
Milsom Ian,
Sandberg Torsten,
Jodal Ulf
Publication year - 2016
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/aogs.12853
Subject(s) - medicine , pregnancy , urinary system , blood pressure , preeclampsia , obstetrics , prospective cohort study , population , genetics , environmental health , biology
Urinary tract infections ( UTI ) during childhood can result in permanent renal damage, with possible implications for future pregnancies. The aim of this prospective study was to investigate pregnancy outcomes in women followed after their first UTI in childhood. Material and methods A cohort of 72 parous women was followed from their first UTI in childhood up to a median age of 41 years. Clinical data were obtained from antenatal and hospital records. Renal damage was evaluated by a 99m Tc‐dimercaptosuccinic acid scan. Pregnancy blood pressure ( BP ), complications and UTI s were compared between women with and without renal damage. Results All women completed the investigations, 48 with and 24 without renal damage. No woman, irrespective of presence or absence of renal damage, was diagnosed with hypertension before the first pregnancy. Pregnancy‐related hypertension was diagnosed in 10 of 151 pregnancies, all in women with renal damage. Preeclampsia occurred in four women. Women with renal damage had significantly higher systolic BP measured at the last antenatal visit of their first pregnancy, compared with women without renal damage ( p = 0.005). During subsequent pregnancies both systolic and diastolic BP were significantly higher in women with than without renal damage ( p = 0.02 and p = 0.03, respectively). Conclusion In this population‐based follow‐up study we found a large proportion of women with renal damage after UTI in childhood. Women with renal damage had significantly higher BP during pregnancy compared with women without renal damage. Pregnancy‐related hypertension was recorded only in women with renal damage. However, pregnancy complications, including preeclampsia, were few.